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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
05/12/2016 |
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Actualizado : |
09/10/2019 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
VERDES, J. M.; MÁRQUEZ, M.; CALLIARI, A.; BATES, D.; MORAÑA, J. A.; GIMENO, E. J.; ODRIOZOLA, E.; GIANNITTI, F.; GUERRERO, F.; FIDALGO, L. E.; PUMAROLA, M. |
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Afiliación : |
JOSÉ MANUEL VERDES, Universidad de la República (UdelaR)/ Facultad de Veterinaria; MEC/ IIBCE (Instituto de Investigaciones de Ciencias Biológicas "Clemente Estable"); MERCEDES MÁRQUEZ, Universidad de Santiago de Compostela (USC); ALDO CALLIARI, Universidad de la República (UdelaR)/ Facultad de Veterinaria; MEC/ IIBCE (Instituto de Investigaciones de Ciencias Biológicas "Clemente Estable"); DANIEL BATES, Universidad de la República (UdelaR)/ Facultad de Veterinaria; JOSÉ ANTONIO MORAÑA, Universidad de la República (UdelaR)/ Facultad de Veterinaria; EDUARDO JUAN GIMENO, Universidad Nacional de la Plata (UNLP); ERNESTO ODRIOZOLA, INTA (Instituto Nacional de Tecnología Agropecuaria)- Balcarce; FEDERICO GIANNITTI, University of Minnesota, Saint Paul, MN, USA; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FLORENTINA GUERRERO, Universidad de Santiago de Compostela (USC); LUIS EUSEBIO FIDALGO, Universidad de Santiago de Compostela (USC); MARTÍ PUMAROLA, Universitat Autònoma de Barcelona. |
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Título : |
A novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. (Full Scientific Report) |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Journal of Veterinary Diagnostic Investigation, 2015, v.27 (3): 278-286. |
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DOI : |
10.1177/1040638715582048 |
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Idioma : |
Inglés |
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Notas : |
Article history: First Published April 21, 2015. |
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Contenido : |
ABSTRACT.
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on these results, we propose that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinje cell degeneration and death.
© 2015 The Author(s). MenosABSTRACT.
Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on th... Presentar Todo |
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Palabras claves : |
BOVINE; CEREBELLAR DEGENERATION; CYTOSKELETAL DYSFUNCTION; PURKINJE CELLS; SOLANUM BONARIENSE. |
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Thesagro : |
BOVINOS. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 02961naa a2200337 a 4500
001 1056202
005 2019-10-09
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1177/1040638715582048$2DOI
100 1 $aVERDES, J. M.
245 $aA novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle. (Full Scientific Report)$h[electronic resource]
260 $c2015
500 $aArticle history: First Published April 21, 2015.
520 $aABSTRACT. Intoxication with Solanum bonariense in cattle causes cerebellar cortical degeneration with perikaryal vacuolation, axonal swelling, and death primarily of Purkinje cells, with accumulation of electron-dense residual storage bodies in membrane-bound vesicles. The pathogenesis of this disease is not fully understood. Previously, we proposed that inhibition of protein synthesis in Purkinje cells among other altered metabolic pathways could lead to cytoskeletal alterations, subsequently altering cell-specific axonal transport. In the present study, immunohistochemical and histochemical methods were used to identify neuronal cytoskeletal alterations and axonal loss, demyelination, and astrogliosis in the cerebellum of intoxicated bovines. Samples of cerebellum from 3 natural and 4 experimental cases and 2 control bovines were studied. Immunoreactivity against neurofilament (NF)-200KDa confirmed marked loss of Purkinje neurons, and phospho-NF protein, ?-tubulin, and affinity reaction against phalloidin revealed an altered perikaryal distribution of neuronal cytoskeletal proteins in the remaining Purkinje cells in intoxicated cattle. Reactive astrogliosis in every layer of the cerebellar cortex was also observed with anti?glial fibrillary acidic protein immunohistochemistry. In affected cattle, demyelination and axonal loss in the cerebellar white matter, as well as basket cell loss were demonstrated with Klüver?Barrera and Bielschowsky stains, respectively. Based on these results, we propose that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinje cell degeneration and death. © 2015 The Author(s).
650 $aBOVINOS
653 $aBOVINE
653 $aCEREBELLAR DEGENERATION
653 $aCYTOSKELETAL DYSFUNCTION
653 $aPURKINJE CELLS
653 $aSOLANUM BONARIENSE
700 1 $aMÁRQUEZ, M.
700 1 $aCALLIARI, A.
700 1 $aBATES, D.
700 1 $aMORAÑA, J. A.
700 1 $aGIMENO, E. J.
700 1 $aODRIOZOLA, E.
700 1 $aGIANNITTI, F.
700 1 $aGUERRERO, F.
700 1 $aFIDALGO, L. E.
700 1 $aPUMAROLA, M.
773 $tJournal of Veterinary Diagnostic Investigation, 2015$gv.27 (3): 278-286.
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Registro original : |
INIA Las Brujas (LB) |
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Biblioteca
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Registro
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
21/12/2023 |
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Actualizado : |
21/12/2023 |
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Tipo de producción científica : |
Artículos en Revistas Agropecuarias |
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Autor : |
PEREYRA, S.; CASTRO, M.; VERO, S.; SILVA, P.; CAL, A.; TISCORNIA, G.; GONZALEZ, N.; BENTOS, D.; ALVAREZ, W.; RABAZA, S.; SEVILLANO, L.; BRANCATTI, G.; FRANCIA, C.; RAFFO, M.A.; GERMAN, S.; PÉREZ, C.; GARMENDIA, G.; PAREJA, L.; RODRÍGUEZ, A.; PENDAS, C.; QUINCKE, M.; VÁZQUEZ, D.; RODRIGUEZ, M. |
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Afiliación : |
SILVIA ANTONIA PEREYRA CORREA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARINA CASTRO DERENYI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SILVANA VERO, Facultad de Química - Udelar; MARIA PAULA SILVA VILLELLA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ADRIAN TABARE CAL ALVAREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GUADALUPE TISCORNIA TOSAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; NESTOR RICARDO GONZALEZ PEREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DAHIANA BENTOS MOYANO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; WILLIAM HORACIO ALVAREZ FIGUEROA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SAMUEL RABAZA SOULIER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LEYDI GIOVANNA SEVILLANO BONILLA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GIANELLA BRANCATTI, Facultad de Química - Udelar; CAROLINA FRANCIA, Facultad de Agronomía, Udelar; MIGUEL ANGEL RAFFO BUSCO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SILVIA ELISA GERMAN FAEDO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS PÉREZ, Facultad de Agronomía, Udelar; GABRIELA GARMENDIA, Facultad de Química - Udelar; LUCÍA PAREJA, CENUR-Litoral Norte, Udelar; ALEJANDRA RODRÍGUEZ, IPTP, Facultad de Química, Udelar; CINTHIA PENDAS, IPTP, Facultad de Química, Udelar; MARTIN CONRADO QUINCKE WALDEN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; DANIEL VÁZQUEZ PEYRONEL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARCELO JULIAN RODRIGUEZ ALONZO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Fusariosis de la espiga en trigo y micotoxinas asociadas: contribuyendo a reducir su riesgo. |
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Complemento del título : |
Cultivos. |
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Fecha de publicación : |
2023 |
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Fuente / Imprenta : |
Revista INIA Uruguay, Diciembre 2023, no.75 p.54-58. |
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Serie : |
(Revista INIA; 75). |
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ISSN : |
1510-9011 |
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Idioma : |
Español |
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Contenido : |
Los avances de la investigación en los últimos 20 años generando conocimientos en la biología y epidemiología de la FE en nuestros sistemas de producción, en la diversidad de las poblaciones de Fusarium y sus toxinas asociadas, y herramientas disponibles para el manejo integrado, asisten en minimizar el riesgo de niveles de micotoxinas y residuos de fungicidas en los granos de trigo por encima de los permitidos. |
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Palabras claves : |
AGROALIMENTOS - INIA; SISTEMA AGRÍCOLA-GANADERO - INIA; SISTEMAS DE INFORMACIÓN Y TRANSFORMACIÓN DIGITAL - INIA. |
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Thesagro : |
FUSARIOSIS DE LA ESPIGA DE TRIGO; TRIGO. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/17456/1/Revista-INIA-75-dic-2023-13.pdf
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Marc : |
LEADER 01719naa a2200469 a 4500
001 1064418
005 2023-12-21
008 2023 bl uuuu u00u1 u #d
022 $a1510-9011
100 1 $aPEREYRA, S.
245 $aFusariosis de la espiga en trigo y micotoxinas asociadas$bcontribuyendo a reducir su riesgo.$h[electronic resource]
260 $c2023
490 $a(Revista INIA; 75).
520 $aLos avances de la investigación en los últimos 20 años generando conocimientos en la biología y epidemiología de la FE en nuestros sistemas de producción, en la diversidad de las poblaciones de Fusarium y sus toxinas asociadas, y herramientas disponibles para el manejo integrado, asisten en minimizar el riesgo de niveles de micotoxinas y residuos de fungicidas en los granos de trigo por encima de los permitidos.
650 $aFUSARIOSIS DE LA ESPIGA DE TRIGO
650 $aTRIGO
653 $aAGROALIMENTOS - INIA
653 $aSISTEMA AGRÍCOLA-GANADERO - INIA
653 $aSISTEMAS DE INFORMACIÓN Y TRANSFORMACIÓN DIGITAL - INIA
700 1 $aCASTRO, M.
700 1 $aVERO, S.
700 1 $aSILVA, P.
700 1 $aCAL, A.
700 1 $aTISCORNIA, G.
700 1 $aGONZALEZ, N.
700 1 $aBENTOS, D.
700 1 $aALVAREZ, W.
700 1 $aRABAZA, S.
700 1 $aSEVILLANO, L.
700 1 $aBRANCATTI, G.
700 1 $aFRANCIA, C.
700 1 $aRAFFO, M.A.
700 1 $aGERMAN, S.
700 1 $aPÉREZ, C.
700 1 $aGARMENDIA, G.
700 1 $aPAREJA, L.
700 1 $aRODRÍGUEZ, A.
700 1 $aPENDAS, C.
700 1 $aQUINCKE, M.
700 1 $aVÁZQUEZ, D.
700 1 $aRODRIGUEZ, M.
773 $tRevista INIA Uruguay, Diciembre 2023, no.75 p.54-58.
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